COPPER-COORDINATION DRIVEN BRAIN-TARGETING NANOASSEMBLY FOR EFFICIENT GLIOBLASTOMA MULTIFORME IMMUNOTHERAPY BY CUPROPTOSIS-MEDIATED TUMOR IMMUNE MICROENVIRONMENT REPROGRAMMING

Abstract Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM).Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) for Baby Tee site-specific delivery of therapeutic agents and efficient immunotherapy by activating the

Published epidemiological studies of traumatic brain injury (TBI) of all severities consistently report higher incidence in men.Recent increases in the participation of women in sports and active military service as well as increasing awareness of the very large number of women who sustain but do not report TBI as a result of intimate partner viole

The paper pleads for the importance of organizational diagnosis in order Wooden Kit to develop new employee-centred strategies.In order to remain competitive, especially in the COVID-19 context, organizations from the IT&C industry needs to improve employee-centred strategies and to align the business processes with these strategies.The empirical r

The Russian Revolution is probably one of the most important events in contemporary world history.This article is an attempt to mark the centenary of the end of the revolution by setting the record straight.It aims to describe a lived experience of mass democracy and popular revolt that “shook the world”; to show that it Baby Tee was the collec

Penelitian ini bertujuan mengevaluasi penerapan metode Penghitungan Kerugian Negara (PKN) di Badan Pemeriksa Keuangan (BPK).Kerangka penelitian menggunakan Policeman Theory yang menekankan tanggung jawab auditor untuk mendeteksi kecurangan.Salah satu dampak akibat terjadinya kecurangan/korupsi dalam pengelolaan keuangan negara adalah timbulnya keru